Our highly experienced process chemists assist our customers with quick optimization of clients’ medicinal chemistry routes to prepare the required large quantities of their drug candidates for pre-clinical developmental studies. The process team at CalChem focuses on rapid and safe scale up of lead compounds and active pharmaceutical ingredients (APIs) for toxicology studies, as well as starting materials, building blocks and intermediates.
 
 
 

 EXAMPLES OF TYPICAL SCALE-UP PROCESSES:

Rapid scale-up of intermediates, lead compounds, and APIs to kilogram quantity following literature procedures or clients’ synthetic routes

Scale-up of chemical entities, following newly developed routes generated by process R&D at CalChem

Scale-up of Proof-of-Concept (POC) batches for toxicology studies